Recombinant Mouse Ecto-Nucleoside Triphosphate Diphosphohydrolase 2/CD39L1 (C-6His)

Cat.No.: CU34

Recombinant Mouse CD39L1 (C-6His)
Description
Recombinant Mouse Ecto-Nucleoside Triphosphate Diphosphohydrolase 2 is produced by our Mammalian expression system and the target gene encoding Cys26-Ser462 is expressed with a 6His tag at the C-terminus.
Accession #:O55026
Known as:Ectonucleoside triphosphate diphosphohydrolase 2; Entpd2
Formulation
Supplied as a 0.2 μm filtered solution of 50mM Tris, 10mM CaCl2, 150mM NaCl, 10% Glycerol, pH 7.5 .
Quality Control
Purity:Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin:Less than 0.1 ng/?g (1 EU/?g) as determined by LAL test.
Storage
Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.
Background
CD39L1 protein (ENTPD2 or NTPDase2) is a member of the ecto-nucleoside triphosphate diphosphohydrolase family which the main role is termination of purinergic signaling. CD39L1 gene encodes a precursor protein with 495 amino acid residues which generates a 437 amino acid residues mature protein after processing. It is an ecto-nucleotidase that found on the surface of vascular adventitial cells and accessory vascular cells. CD39L1 is a Ca2+- and Mg2+-dependent enzyme that activates platelets by preferentially converting ATP to ADP. CD39L1 plays a role in regulating thrombosis and inflammation which is considered to be a therapeutic target for thromboregulation and the treatment of vascular inflammation. Alternative splicing of CD39L1 gene results in multiple transcript variants.

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