GDF15 Antigen

Cat.No.: DRA26

Derived From:
E.coli
Description:
Recombinant Human GDF15 is produced by our E.coli expression system and the target gene encoding Ala197-Ile308 is expressed.
Accession:
Q99988
Names(Known as):
GDF15; GDF-15; growth differentiation factor 15; growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; NAG-1; PDF; PDFGDF-15; PLAB; PLABNRG-1
Quality Control:
Mol Mass:
12.3kDa
AP Mol Mass:
14kDa, reducing conditions
Purity:
Greater than 90% as determined by reducing SDS-PAGE.
Formulation:
Supplied as a 0.2 μM filtered solution of 10mM NaAc, pH 4.0.
Shipping:
The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.
Storage:
Reconstituted protein solution should be stored at ≤ -20°C.
Purification:
Affinity purification chromatography.
Immunoreactivity:
N.A.
Application:
Immunogen, calibrator or standard.
Background:
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), Placental Transforming Growth Factor beta, Prostate-derived Factor, and Placental Bone Morphogenetic Protein, is a divergent member of the TGF-beta superfamily. Similar to other TGF-beta family proteins, the GDF-15 proprotein is cleaved at a dibasic cleavage site (RxxR) to release the mature protein. The C-terminal domain of GDF-15 contains seven characteristic conserved cysteine residues necessary for the formation of the cysteine knot and the single interchain disulfide bond. Biologically active GDF-15 is a disulfide-linked homodimer of the mature protein and signals through the heterodimeric receptor composed of TGF-beta RI/ALK-5 and TGF-beta RII. GDF-15 has been shown to have various functions, including inhibition of TNF-alpha production from lipopolysaccharide-stimulated macrophages and the induction of cartilage formation. GDF-15 also promotes neuronal survival, and hypothalamic expression of GDF-15 causes appetite suppression via modulation of Neuropeptide Y and Pro-opiomelanocortin levels. GDF-15 is cardioprotective via inhibition of platelet activation, limiting atherosclerosis, inhibiting CXCL1-induced neutrophil adhesion, regulating angiogenesis, and inhibiting norepinephrine-induced mycardial hypertrophy.
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY

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