Recombinant Human IGFBP3 is produced by our Mammalian expression system and the target gene encoding Gly28-Lys291 is expressed with a 6His tag at the C-terminus.
insulin-like growth factor binding protein 3; IGFBP-3
AP Mol Mass:
38-55kDa, reducing conditions
Greater than 95% as determined by reducing SDS-PAGE.
Supplied as a 0.2 μM filtered solution of 40mM NaAc, pH 4.0.
The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.
Reconstituted protein solution should be stored at ≤ -20°C.
Affinity purification chromatography.
Immunogen, calibrator or standard.
Human IGFBP-3 is the major binding protein of IGF where it exists in circulation as a ternary complex with the acid-labile subunit (ALS).Human IGFBP?-3 cDNA encodes a 291 amino acid (aa) precursor protein with a 27 aa signal peptide that is processed to generate the 264 aa mature protein. Human IGFBP-3 includes a cysteine-rich C-terminal domain, a highly variable central linker domain, and another N-terminal cystein-e?rich domain.IGFBP3 is the most abundant IGF binding protein in human serum and has been shown to be a growth inhibitory, apoptosis-inducing molecule. It appears to function both by cell cycle blockade and the induction of apoptosis.
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY