NT-proBNP Antigen

Cat.No.: DCM29

Derived From:
E.coli
Description:
Recombinant human NT-proBNP is produced by E. coli expression system and the target protein encoding His27-Arg102 is expressed of Human NPPB fused with a 6His tag and FLAG tag at the N-terminus.
Accession:
P16860
Names(Known as):
Amino terminal human brain natriuretic peptide precursor, NT-proBNP
Quality Control:
Mol Mass:
11kDa
AP Mol Mass:
14kDa, reducing conditions
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
Formulation:
Supplied as a 0.2 μM filtered solution of PBS, pH7.4.
Shipping:
The product is shipped on dry ice pack. Upon receipt, store it immediately at the temperature listed below.
Storage:
Reconstituted protein solution should be stored at ≤ -20°C.
Purification:
Affinity purification chromatography.
Immunoreactivity:
Confirmed by reaction with monoclonal antibodies specific to different fragments of NTproBNP.
Application:
Immunogen, calibrator or standard.
Background:
Brain-type Natriuretic Peptide (BNP) is a nonglycosylated peptide that is produced predominantly by ventricular myocytes and belongs to the natriuretic peptide family. Proteolytic cleavage of the 12 kDa BNP precursor gives rise to N-terminal Pro BNP (NT-proBNP) and mature BNP. N-terminal proB-type natriuretic peptide (NT-proBNP), a useful marker of heart failure (HF), is considered to be secreted mainly from the ventricle, increased serum NT-proBNP levels are also encountered in conditions such as atrial fibrillation (AF) and atrial septal defect in patients without HF.
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY

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