Recombinant Human TPO is produced by our Mammalian expression system and the target gene encoding Phe19-Arg846 (A257S,T725P) is expressed with a 6His tag at the C-terminus.
Thyroid peroxidase; TPO
AP Mol Mass:
90-120kDa, reducing conditions
Greater than 95% as determined by reducing SDS-PAGE.
Supplied as a 0.2 μM filtered solution of 20mM Tris-HCl, 500mM NaCl, 10% Glycerol, pH 8.0.
The product is shipped on dry ice pack. Upon receipt, store it immediately at the temperature listed below.
Reconstituted protein solution should be stored at ≤ -20°C.
Affinity purification chromatography.
Antigen was assessed by commercial kits.
Immunogen, calibrator or standard.
TPO acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Diseases associated with TPO include Thyroid Dyshormonogenesis 2A and Congenital Hypothyroidism.
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY