tTG Antigen

Cat.No.: DE056

Derived From:
E.coli
Description:
Recombinant Human Tissue Transglutaminase/tTG is produced by E.coli expression system and the target gene encoding Met1-Ala687 is expressed with a 6His tag at the N-terminus.
Accession:
P21980
Names(Known as):
Tissue transglutaminase;Protein-glutamine gamma-glutamyltransferase 2;TGC;TGM2
Quality Control:
Mol Mass:
79.5kDa
AP Mol Mass:
90kDa, reducing conditions
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
Formulation:
Supplied as a 0.2 μM filtered solution of 50mM Tris, 100mM NaCl, 2mM DTT, 20%Glycerol,PH8.0.
Shipping:
The product is shipped on dry ice pack. Upon receipt, store it immediately at the temperature listed below.
Storage:
Reconstituted protein solution should be stored at ≤ -20°C.
Purification:
Affinity purification chromatography.
Immunoreactivity:
N.A.
Application:
Immunogen, calibrator or standard.
Background:
Transglutaminase 2 (TG2), encoded by the TGM2 gene, is also known as tissue transglutaminase (tTG), transgluytaminase C (TGC), and protein-glutamine-gamma -glutamyltransferase. It belongs to the family of transglutaminases that catalyze the posttranslational modification of proteins via calcium dependent cross-linking reactions. In addition to its function in protein cross-linking, TGM2 is also capable of hydrolyzing both GTP and ATP and has intrinsic kinase activity. TGM2 has been implicated in a variety of human diseases including celiac disease, inclusion body myositis, atherosclerosis, and neurodegenerative diseases.
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY

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