Recombinant Human FGL1 (C-6His)

Cat.No.: CW55

Recombinant Human FGL1 (C-6His)
Description
Recombinant Human Fibrinogen-like Protein 1 is produced by our Mammalian expression system and the target gene encoding Leu23-Ile312 is expressed with a 6His tag at the C-terminus.
Accession #:Q08830
Known as:Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris,300mM NaCl, 10% Glycerol,2mMEDTA,pH 8.0.
Quality Control
Purity:Greater than 90% as determined by reducing SDS-PAGE.
BioActivity:Immobilized Human FGL1-His (Cat#CW55) at 5μg/ml (100 μl/well) can bind Human LAG-3-Fc (Cat#CU30).
Endotoxin:Less than 0.1 ng/?g (1 EU/?g)
Storage
Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.
Background
Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3 .

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