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Recombinant Human B2M (C-6His)(Cat. No.:C512)
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1mg
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Description
Recombinant Human Beta-2-Microglobulin is produced by our Mammalian expression system and the target gene encoding Ile21-Met119 is expressed with a 6His tag at the C-terminus.
Accession
P61769
Known As
Beta-2-Microglobulin; B2M
Mol Mass
12.77 KDa
APMol Mass
14 KDa, reducing conditions
Formulation Description
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Endotoxin
< 1 EU/µg as determined by LAL test.
Purity-SDS-PAGE
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Purity-SEC-HPLC
Greater than 95% as determined by SEC-HPLC. (QC verified)
Bioactivity-BLI
Loaded Recombinant Human B2M (C-6His)(Cat#C512) on HIS1K Biosensor, can bind Human B2M Antibody with an affinity constant of 4.56 pM as determined in BLI assay. (Regularly tested)
Reconstitution
  • Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
  • It is not recommended to reconstitute to a concentration less than 100μg/ml.
  • Dissolve the lyophilized protein in distilled water.
  • Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Storage
  • Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
  • Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
  • Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping
  • The product is shipped at ambient temperature.
  • Upon receipt, store it immediately at the temperature listed below.
Background
β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.
仅供科研或生产使用,不可直接应用于人体。
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