Recombinant Human ACADM/MCAD (N-6His)

Cat.No.: CF46

Recombinant Human ACADM (N-6His)
Recombinant Human Medium-Chain Specific Acyl-CoA Dehydrogenase, Mitochondrial is produced by our E.coli expression system and the target gene encoding Lys26-Asn421 is expressed with a 6His tag at the N-terminus.
Accession #:P11310
Known as:Medium-Chain Specific Acyl-CoA Dehydrogenase Mitochondrial; MCAD; ACADM
Supplied as a 0.2 μm filtered solution of 20mM Tris, 100mM Nacl, 20% Glycerol, pH 8.5.
Quality Control
Purity:Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin:Less than 0.1 ng/?g (1 EU/?g) as determined by LAL test.
Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.
Medium-Chain Specific Acyl-CoA Dehydrogenase (ACADM) is a mitochondrial fatty acid beta-oxidation that belongs to the acyl-CoA dehydrogenase family. ACADM is a homotetramer enzyme that catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. ACADM is specific for acyl chain lengths of 4 to 16. It is essential for converting these particular fatty acids to energy, especially during fasting periods. Defects in ACADM cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death.

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