Recombinant Human Homeobox Protein Hox-B4/HOXB4/HOX-2F (N-6His)

Cat.No.: CK28

Recombinant Human HOXB4 (N-6His)
Description
Recombinant Human Homeobox protein B4 is produced by our E.coli expression system and the target gene encoding Met1-Leu251 is expressed with a 6His tag at the N-terminus.
Accession #:P17483
Known as:Homeobox protein Hox-B4; Homeobox protein Hox-2.6; Homeobox protein Hox-2F; HOXB4; HOX2F
Formulation
Supplied as a 0.2 μm filtered solution of 4mM HCl.
Quality Control
Purity:Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin:Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Storage
Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.
Background
Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation of stem cells whilst activating the apoptotic pathway in some embryonic structures. The protein HOXB4, as a homeodomain transcription factor, has been shown to be an important regulator of stem cell renewal and hematopoiesis. Incellular or ectopic expression of HOXB4 expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

Send Message